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Interleukin IL -8 is a proinflammatory cytokine, and high levels of IL-8 are associated with poor prognosis in many malignancies. The objective of this study was to explore the clinical benefit of monitoring plasma IL-8 levels during breast cancer chemotherapy. We conducted an exploratory analysis of several circulating proteins, including IL-8, in the plasma.

Plasma samples were obtained from 58 metastatic breast cancer patients who took part in a prospective phase 2 first-line bevacizumab chemotherapy trial.

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Samples were analyzed before therapy, after 6 weeks and 6 months of treatment, and at the final study visit. On the basis of a trajectory analysis of the plasma IL-8 levels, the patients were divided into 3 trajectory groups. Low IL-8 levels during chemotherapy treatment might help identify patients with prolonged survival.

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Under a Creative Commons. Abstract Background Interleukin IL -8 is a proinflammatory cytokine, and high levels of IL-8 are associated with poor prognosis in many malignancies.

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Patients and Methods We conducted an exploratory analysis of several circulating proteins, including IL-8, in the plasma. Conclusion Low IL-8 levels during chemotherapy treatment might help identify patients with prolonged survival.

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Keywords Bevacizumab. Recommended articles Citing articles 0. Published by Elsevier Inc.

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